Parechovirus B

Parechovirus B
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family: Picornaviridae
Genus: Parechovirus
Species:
Parechovirus B
Synonyms
  • Ljungan virus[1]

Parechovirus B, formerly called the Ljungan virus, was first discovered in the mid-1990s after being isolated from a bank vole near the Ljungan river in Medelpad county, Sweden.[2] It has since been established that Parechovirus B, which is also found in several places in Europe and America, causes serious illness in wild as well as laboratory animals.[3][4][5][6] Several scientific articles have recently reported findings indicating that Parechovirus B is associated with malformations, intrauterine fetal death, and sudden infant death syndrome in humans.[7][8][9][10] In addition, studies are being conducted worldwide to investigate the possible connection of the virus to diabetes, neurological and other illnesses in humans.[citation needed]

Parechovirus B belongs to the genus Parechovirus of the family Picornaviridae. Other members of this viral family include poliovirus, Hepatovirus A, and the viruses causing the common cold (rhinovirus).[11] One of the earliest scientific discoveries regarding Parechovirus B was that infected wild rodents developed diabetes if they were exposed to stress.[12] This has led to speculation that this disease may be the underlying cause of fluctuating rodent populations in Scandinavia; when rodents increase to high densities, they find it difficult to defend territory and obtain food, and then become more susceptible to predation. This stressful situation results in disease, death and population decline, leading to a pattern of cyclic variation in population size over time.[4]

  1. ^ Knowles, Nick (7 July 2014). "Rename 12 picornavirus species" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved 1 May 2019. Parechovirus Ljungan virus Parechovirus B Ljungan virus 1-4
  2. ^ Niklasson, B.; Hörnfeldt, Birger; Hörling, Jan; et al. (1999). "A new picornavirus isolated from bank voles (Clethrionomys glareolus)". Virology. 255 (1): 86–93. doi:10.1006/viro.1998.9557. PMID 10049824.
  3. ^ Main, A.J.; R.E. Shope & R.C. Wallis (1976). "Characterization of Whitney's Clethrionomys gapperi virus isolates from Massachusetts". J Wildl Dis. 12 (2): 154–64. doi:10.7589/0090-3558-12.2.154. PMID 6801. S2CID 31369232.
  4. ^ a b Niklasson, B.; Feinstein, Ricardo E.; Samsioe, Annika; et al. (2006). "Diabetes and myocarditis in voles and lemmings at cyclic peak densities--induced by Ljungan virus?". Oecologia. 150 (1): 1–7. Bibcode:2006Oecol.150....1N. doi:10.1007/s00442-006-0493-1. PMID 16868760. S2CID 22311201.
  5. ^ Samsioe, A.; Saade, George; Sjöholm, Åke; et al. (2006). "Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice". Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77 (4): 251–56. doi:10.1002/bdrb.20083. PMID 16894624.
  6. ^ Salisbury, A. M.; Begon, M.; Dove, W.; Niklasson, B.; Stewart, J. P. (2013). "Ljungan virus is endemic in rodents in the UK". Archives of Virology. 159 (3): 547–51. doi:10.1007/s00705-013-1731-6. PMID 23665770. S2CID 15595591.
  7. ^ Niklasson, B.; Schønecker, Bryan; Bildsøe, Mogens; et al. (2003). "Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus". Int J Exp Diabesity Res. 4 (1): 35–44. doi:10.1080/15438600303733. PMC 2480497. PMID 12745669.
  8. ^ Niklasson, B.; Papadogiannakis, Nikos; Gustafsson, Susanne; et al. (2009). "Zoonotic Ljungan virus associated with central nervous system malformations in terminated pregnancy". Birth Defects Res. A. 85 (6): 542–55. doi:10.1002/bdra.20568. PMID 19180651.
  9. ^ Niklasson, B.; Hörnfeldt, Birger; Klitz, William (2009). "Sudden infant death syndrome and Ljungan virus". Forensic Sci Med Pathol. 5 (4): 274–9. doi:10.1007/s12024-009-9086-8. PMID 19408134. S2CID 25470667.
  10. ^ Niklasson, B.; et al. (2007). "Association of zoonotic Ljungan virus with intrauterine fetal deaths". Birth Defects Research Part A: Clinical and Molecular Teratology. 79 (6): 488–93. doi:10.1002/bdra.20359. PMID 17335057.
  11. ^ Joki-Korpela, P.; T. Hyypia (2001). "Parechoviruses, a novel group of human picornaviruses". Ann Med. 33 (7): 466–71. doi:10.3109/07853890109002095. PMID 11680794. S2CID 37499760.
  12. ^ Schoenecker, B.; K.E. Heller & T. Freimanis (2000). "Development of stereotypies and polydipsia in wild caught bank voles (Clethrionomys glareolus) and their laboratory-bred offspring. Is polydipsia a symptom of diabetes mellitus?". Appl Anim Behav Sci. 68 (4): 349–357. doi:10.1016/S0168-1591(00)00108-8. PMID 10844158.