Pathogenomics is a field which uses high-throughput screening technology and bioinformatics to study encoded microbe resistance, as well as virulence factors (VFs), which enable a microorganism to infect a host and possibly cause disease.[1][2][3][4] This includes studying genomes of pathogens which cannot be cultured outside of a host.[5] In the past, researchers and medical professionals found it difficult to study and understand pathogenic traits of infectious organisms.[6] With newer technology, pathogen genomes can be identified and sequenced in a much shorter time and at a lower cost,[7][8] thus improving the ability to diagnose, treat, and even predict and prevent pathogenic infections and disease.[9] It has also allowed researchers to better understand genome evolution events - gene loss, gain, duplication, rearrangement - and how those events impact pathogen resistance and ability to cause disease.[8] This influx of information has created a need for bioinformatics tools and databases to analyze and make the vast amounts of data accessible to researchers,[10][11] and it has raised ethical questions about the wisdom of reconstructing previously extinct and deadly pathogens in order to better understand virulence.[12]