Pauline Spender-Clay (née Astor; 24 September 1880 – 5 April 1972) was an American-English socialite known for her hospitality; her gardening, especially the cultivation of lilies; and her portrait painted by John Singer Sargent. Like many American heiresses, her engagements were a subject of speculation before her marriage. She volunteered as a Voluntary Aid Detachment nurse in World War I and opened up her house, Ford Manor, to be used as a military hospital in both World Wars. She was a member of the Astor family.