| Clinical data | |
|---|---|
| Trade names | PegIntron, Sylatron, ViraferonPeg, others |
| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a605030 |
| Routes of administration | Subcutaneous injection |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Elimination half-life | 22–60 hrs |
| Identifiers | |
| |
| CAS Number | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| ChEMBL | |
| ECHA InfoCard | 100.208.164 |
| Chemical and physical data | |
| Formula | C860H1353N229O255S9 |
| Molar mass | 19269.17 g·mol−1 |
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Pegylated interferon alfa-2b is a drug used to treat melanoma, as an adjuvant therapy to surgery.[3] Also used to treat hepatitis C (typically, in combination with ribavarin), it is no longer recommended due to poor efficacy and adverse side-effects.[4] Subcutaneous injection is the preferred delivery method.[3]
Belonging to the alpha interferon family of medications, the molecule is PEGylated to prevent breakdown.[3][4] Approval for medical use in the United States was granted in 2001.[3] It is on the World Health Organization's List of Essential Medicines as a therapy for chronic hepatitis C.[5][6]
- ^ "PegIntron- peginterferon alfa-2b injection, powder, lyophilized, for solution PegIntron- peginterferon alfa-2b kit". DailyMed. Retrieved 28 September 2020.
- ^ "Sylatron- peginterferon alfa-2b kit". DailyMed. 28 August 2019. Retrieved 28 September 2020.
- ^ a b c d "Peginterferon Alfa-2b (Professional Patient Advice) - Drugs.com". www.drugs.com. Archived from the original on 16 January 2017. Retrieved 12 January 2017.
- ^ a b "Peginterferon alfa-2b (PegIntron)". Hepatitis C Online. Infectious Diseases Education & Assessment, University of Washington. January 2021. Retrieved 12 January 2017.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Retrieved 21 May 2021.