Pennsylvania Avenue is a street in Washington, D.C. and its suburbs on which some major landmarks, including the White House and the United States Capitol, are located.
Pennsylvania Avenue may also refer to:
- Pennsylvania Avenue (Baltimore), a street in Baltimore, Maryland
- Pennsylvania Avenue, a portion of Connecticut Route 161
- Delaware Route 52 or Pennsylvania Avenue
- Pennsylvania Avenue (Towson, Maryland), a street in Towson's central business district
- Pennsylvania Avenue (Brooklyn), a major street in Brooklyn, New York
- Pennsylvania Avenue, a property in Monopoly (game)
- Pennsylvania Avenue (IRT New Lots Line), a New York City Subway station in Brooklyn
- Pennsylvania Avenue (BMT Fulton Street Line), a former New York City elevated railway station in Brooklyn
- West Virginia Route 105 or Pennsylvania Avenue
- Penn Avenue in Pittsburgh, Pennsylvania