Pentoxifylline

Pentoxifylline
Clinical data
Pronunciation	/ˌpɛntɒkˈsɪfɪliːn, -ɪn/
Trade names	Trental, many other names worldwide
Other names	oxpentifylline (former AAN)
AHFS/Drugs.com	Monograph
MedlinePlus	a685027
License data	US FDA: Pentoxifylline;
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
ATC code	C04AD03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	10–30%
Metabolism	Hepatic and via erythrocytes
Elimination half-life	0.4–0.8 hours (1–1.6 hours for active metabolite)
Excretion	Urine (95%), faeces (<4%)
Identifiers
	IUPAC name 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione;
CAS Number	6493-05-6 ;
PubChem CID	4740;
IUPHAR/BPS	7095;
DrugBank	DB00806 ;
ChemSpider	4578 ;
UNII	SD6QCT3TSU;
KEGG	D00501 ;
ChEMBL	ChEMBL628 ;
CompTox Dashboard (EPA)	DTXSID7023437 ;
ECHA InfoCard	100.026.704
Chemical and physical data
Formula	C13H18N4O3
Molar mass	278.312 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ncn(c1C(=O)N2CCCCC(=O)C)C)C;
	InChI InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3 ; Key:BYPFEZZEUUWMEJ-UHFFFAOYSA-N ;
	(verify)

Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease.^[4] It is generic and sold under many brand names worldwide.^[1]

^ ^a ^b Drugs.com drugs.com international listings for Pentoxifylline. Page accessed Feb 1, 206
^ "PRODUCT INFORMATION TRENTAL® 400" (PDF). TGA eBusiness Services. sanofi-aventis australia pty limited. 25 March 2010. Retrieved 3 February 2014.
^ ^a ^b ^c "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 February 2014.
^ Broderick C, Forster R, Abdel-Hadi M, Salhiyyah K (October 2020). "Pentoxifylline for intermittent claudication". The Cochrane Database of Systematic Reviews. 2020 (10): CD005262. doi:10.1002/14651858.CD005262.pub4. PMC 8094235. PMID 33063850.

[generics-1] Drugs.com drugs.com international listings for Pentoxifylline. Page accessed Feb 1, 206

[TGA-2] "PRODUCT INFORMATION TRENTAL® 400" (PDF). TGA eBusiness Services. sanofi-aventis australia pty limited. 25 March 2010. Retrieved 3 February 2014.

[MSR-3] "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 February 2014.

[:0-4] Broderick C, Forster R, Abdel-Hadi M, Salhiyyah K (October 2020). "Pentoxifylline for intermittent claudication". The Cochrane Database of Systematic Reviews. 2020 (10): CD005262. doi:10.1002/14651858.CD005262.pub4. PMC 8094235. PMID 33063850.

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