Pentoxyverine

Pentoxyverine
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa606008
Pregnancy
category
  • No studies; contraindicated
Routes of
administration		Oral, rectal
ATC code
Pharmacokinetic data
MetabolismHepatic
Elimination half-life2.3 hours (oral), 3–3.5 hours (rectal)
ExcretionRenal
Identifiers
  • 2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.923 Edit this at Wikidata
Chemical and physical data
FormulaC20H31NO3
Molar mass333.472 g·mol−1
3D model (JSmol)
Melting point90 to 95 °C (194 to 203 °F)
Solubility in watergood
  • O=C(OCCOCCN(CC)CC)C2(c1ccccc1)CCCC2
  • InChI=1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3 checkY
  • Key:CFJMRBQWBDQYMK-UHFFFAOYSA-N checkY
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Pentoxyverine (rINN) or carbetapentane is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold. It is sold over-the-counter as Solotuss,[1] or in combination with other medications, especially decongestants. One such product is Certuss, a combination of guaifenesin and pentoxyverine.[2] The drug has been available in the form of drops, suspensions and suppositories.[1][3]

It was formerly available over-the-counter in United States. However, the U.S. Food & Drug Administration ruled in 1987 that pentoxyverine was not generally recognized as safe and effective and ordered it to be removed from the over-the-counter market.[4]

  1. ^ a b "Carbetapentane". Drugs.com. Archived from the original on 2008-07-26. Retrieved 2018-01-23.
  2. ^ "Certuss". Drugs.com.
  3. ^ Jasek W, ed. (2008). Austria-Codex (in German) (63 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-188-3.
  4. ^ Shuren J (November 30, 2007). "Technical Amendment: Removes carbetapentane citrate from 21 CFR 310.201(a)(20)" (PDF). Govinfo. Food and Drug Administration. Archived from the original (PDF) on April 6, 2021. Retrieved November 3, 2023.