Pentraxins

Pentaxin family
CRP drawn from PDB: 1B09
Identifiers
SymbolPentaxin
PfamPF00354
InterProIPR001759
PROSITEPDOC00261
SCOP21sac / SCOPe / SUPFAM
CDDcd00152
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1limD:32-237 2a3wF:26-219 2a3xH:26-219

1lgnC:26-219 2a3yD:26-219 1gykA:26-219 1sacC:26-219 1hasB:29-222 1crvE:25-220

1lj7D:25-220 1b09C:25-220 1gnhA:25-220

Pentraxins (PTX), also known as pentaxins, are an evolutionary conserved family of proteins characterised by containing a pentraxin protein domain. Proteins of the pentraxin family are involved in acute immunological responses.[1] They are a class of pattern recognition receptors (PRRs). They are a superfamily of multifunctional conserved proteins, some of which are components of the humoral arm of innate immunity and behave as functional ancestors of antibodies (Abs). They are known as classical acute phase proteins (APP), known for over a century.[2]

  1. ^ Gewurz H, Zhang XH, Lint TF (February 1995). "Structure and function of the pentraxins". Current Opinion in Immunology. 7 (1): 54–64. doi:10.1016/0952-7915(95)80029-8. PMID 7772283.
  2. ^ Martinez de la Torre Y, Fabbri M, Jaillon S, Bastone A, Nebuloni M, Vecchi A, et al. (May 2010). "Evolution of the pentraxin family: the new entry PTX4". Journal of Immunology. 184 (9): 5055–64. doi:10.4049/jimmunol.0901672. PMID 20357257.