Pepe is a masculine given name and a surname.
Pepe or PEPE may also refer to:
- Pepe (1960 film), a film directed by George Sidney
- Pepe (2024 film), an upcoming Dominican Republic drama film
- "Pepe" (song), featured in the 1960 film
- Pepe (textiles), secondhand clothes popular in Haiti
- Pepe Jeans, a European denim and casual wear company
- Pepe's, a restaurant in New Haven, Connecticut, US
- Parallel Element Processing Ensemble, a computer system
- Pepe the Frog, internet meme