Periamygdaloid cortex

Periamygdaloid cortex
Details
Identifiers
Latincortex periamygdaloideus
MeSHD066277
NeuroNames166
NeuroLex IDnlx_144210
TA98A14.1.09.415
TA25550
FMA62485
Anatomical terms of neuroanatomy

Periamygdaloid cortex (or periamygdalar area) is a portion of the rhinencephalon consisting of paleocortex. It is a cortical-like nucleus of the amygdaloid complex. Though considered a nucleus, the periamygdalar area is more commonly associated with cortex due to its layered structure and location on the outer surface of the brain.[1]

The periamygdaloid cortex is located on the dorsal surface of the brain bordered by the piriform cortex, entorhinal cortex, perirhinal cortex, periamygdalar claustrum, and anterior amygdaloid area.[2] Its ventromedial and dorsolateral borders are defined by the first myelin bundle of the external capsule, while its remaining borders show no myelinated fiber projections or inputs as well as a higher density of acetylcholinesterase and cholinergic synapses than the neighboring anterior amygdaloid area.[2]

The periamygdaloid cortex plays a role in olfaction,[3] and recent studies have shown that it may be involved in many more processes including opiate addiction,[4] assessment of negative emotions,[5] and depression.[4] Additionally, it has been suggested that the left periamygdalar region may play a role in yawning.[6]

  1. ^ Sah, P.; Faber, E. S. L.; Lopez De Armentia, M.; Power, J. (July 2003). "The amygdaloid complex: anatomy and physiology". Physiological Reviews. 83 (3): 803–834. doi:10.1152/physrev.00002.2003. ISSN 0031-9333. PMID 12843409.
  2. ^ a b García-Amado, María; Prensa, Lucía (2012-06-13). "Stereological Analysis of Neuron, Glial and Endothelial Cell Numbers in the Human Amygdaloid Complex". PLOS ONE. 7 (6): e38692. doi:10.1371/journal.pone.0038692. ISSN 1932-6203. PMC 3374818. PMID 22719923.
  3. ^ Majak, Katarzyna; Pitkänen, Asia (2003). "Projections from the periamygdaloid cortex to the amygdaloid complex, the hippocampal formation, and the parahippocampal region: a PHA-L study in the rat". Hippocampus. 13 (8): 922–942. doi:10.1002/hipo.10134. ISSN 1050-9631. PMID 14750655. S2CID 29706209.
  4. ^ a b Anderson, Sarah Ann R.; Michaelides, Michael; Zarnegar, Parisa; Ren, Yanhua; Fagergren, Pernilla; Thanos, Panayotis K.; Wang, Gene-Jack; Bannon, Michael; Neumaier, John F. (2013-12-02). "Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression". Journal of Clinical Investigation. 123 (12): 5334–5341. doi:10.1172/jci70395. ISSN 0021-9738. PMC 3859405. PMID 24231353.
  5. ^ Kilts, Clinton D.; Egan, Glenn; Gideon, Deborah A.; Ely, Timothy D.; Hoffman, John M. (2003). "Dissociable Neural Pathways Are Involved in the Recognition of Emotion in Static and Dynamic Facial Expressions". NeuroImage. 18 (1): 156–168. doi:10.1006/nimg.2002.1323. PMID 12507452. S2CID 17223464.
  6. ^ Schürmann M, Hesse MD, Stephan KE, et al. (February 2005). "Yearning to yawn: the neural basis of contagious yawning". NeuroImage. 24 (4): 1260–4. doi:10.1016/j.neuroimage.2004.10.022. PMID 15670705. S2CID 6269514.