Perilipin-2

PLIN2
Identifiers
Aliases	PLIN2, ADFP, ADRP, Adipose differentiation-related protein, perilipin 2
External IDs	OMIM: 103195; MGI: 87920; HomoloGene: 872; GeneCards: PLIN2; OMA:PLIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	19,149,290 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	86,670,060 bp
RNA expression pattern
	Top expressed in
	pericardium; ; jejunal mucosa; ; beta cell; ; gastrocnemius muscle; ; stromal cell of endometrium; ; right lobe of liver; ; duodenum; ; kidney tubule; ; subcutaneous adipose tissue; ; muscle of thigh;
	Top expressed in
	lactiferous gland; ; left lobe of liver; ; brown adipose tissue; ; tunica adventitia of aorta; ; skin of external ear; ; white adipose tissue; ; stroma of bone marrow; ; fetal liver hematopoietic progenitor cell; ; subcutaneous adipose tissue; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Orthologs
	123
	11520
	ENSG00000147872
	ENSMUSG00000028494
	Q99541
	P43883
	NM_001122
	NM_007408
	NP_001113
NP_031434; NP_001390640; NP_001390641; NP_001390642; NP_001390643;
	NP_001390644; NP_001390645; NP_001390646; NP_001390647; NP_001390648; NP_001390649; NP_001390650; NP_001390651
	Wikidata
View/Edit Human	View/Edit Mouse

Adipose differentiation-related protein, also known as perilipin 2, ADRP or adipophilin, is a protein which belongs to the perilipin (PAT) family of cytoplasmic lipid droplet (CLD)–binding proteins.^[5] In humans it is encoded by the ADFP gene.^[6] This protein surrounds the lipid droplet along with phospholipids and is involved in assisting the storage of neutral lipids within the lipid droplets.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147872 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028494 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Orlicky DJ, Degala G, Greenwood C, Bales ES, Russell TD, McManaman JL (September 2008). "Multiple functions encoded by the N-terminal PAT domain of adipophilin". Journal of Cell Science. 121 (Pt 17): 2921–9. doi:10.1242/jcs.026153. PMC 3139108. PMID 18697835.
^ "Entrez Gene: ADFP adipose differentiation-related protein".
^ Conte M, Franceschi C, Sandri M, Salvioli S (September 2016). "Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective". Trends in Endocrinology and Metabolism. 27 (12): 893–903. doi:10.1016/j.tem.2016.09.001. PMID 27659144. S2CID 3651182.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147872 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Orlicky DJ, Degala G, Greenwood C, Bales ES, Russell TD, McManaman JL (September 2008). "Multiple functions encoded by the N-terminal PAT domain of adipophilin". Journal of Cell Science. 121 (Pt 17): 2921–9. doi:10.1242/jcs.026153. PMC 3139108. PMID 18697835.

[entrez-6] "Entrez Gene: ADFP adipose differentiation-related protein".

[pmid27659144-7] Conte M, Franceschi C, Sandri M, Salvioli S (September 2016). "Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective". Trends in Endocrinology and Metabolism. 27 (12): 893–903. doi:10.1016/j.tem.2016.09.001. PMID 27659144. S2CID 3651182.

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