Perilipin 5, also known as Oxpatperilipin 5 or PLIN5, is a protein that belongs to perilipin family. This protein group has been shown to be responsible for lipid droplet's biogenesis, structure and degradation.[5] In particular, Perilipin 5 is a lipid droplet-associated protein whose function is to keep the balance between lipolysis and lipogenesis, as well as maintaining lipid droplet homeostasis. For example, in oxidative tissues, muscular tissues and cardiac tissues, PLIN5 promotes association between lipid droplets and mitochondria.[6]
Inside the cell, PLIN5 can be found in multiple intracellular structures including lipid droplets, endoplasmic reticulum, mitochondria, and the cytosol.[7] The wrong expression of this protein has been proven to be related with diseases such as skeletal muscle diseases, liver diseases or carcinogenesis.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000214456 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011305 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lipid droplet biogenesis, structure and degradation are regulated, Hashani M, Witzel HR, Pawella LM, Lehmann-Koch J
- ^ Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization. Kimmel AR, Sztalryd C.
- ^ R. Mason, Rachael (2014). "PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle". Molecular Metabolism. 3 (6): 652–63. doi:10.1016/j.molmet.2014.06.002. PMC 4142393. PMID 25161888.
- ^ Widespread expression of perilipin 5 in normal human tissues and in diseases is restricted to distinct lipid droplet subpopulations. Hashani M, Witzel HR, Pawella LM