Period circadian protein homolog 1

PER1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UL6
Identifiers
Aliases	PER1, PER, RIGUI, hPER, period circadian clock 1, period circadian regulator 1
External IDs	OMIM: 602260; MGI: 1098283; HomoloGene: 1966; GeneCards: PER1; OMA:PER1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,156,506 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,000,786 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; tibial nerve; ; skin of leg; ; skin of abdomen; ; right ovary; ; left ovary; ; tibial arteries; ; right lung; ; left uterine tube; ; anterior pituitary;
	Top expressed in
	granulocyte; ; muscle of thigh; ; superior frontal gyrus; ; plantaris muscle; ; extensor digitorum longus muscle; ; neural layer of retina; ; lacrimal gland; ; ankle; ; primary visual cortex; ; stroma of bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; transcription cis-regulatory region binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; E-box binding; kinase binding; chromatin DNA binding; ubiquitin protein ligase binding; protein binding; transcription corepressor binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	histone H3 deacetylation; negative regulation of glucocorticoid receptor signaling pathway; regulation of transcription, DNA-templated; response to light stimulus; regulation of cytokine production involved in inflammatory response; regulation of sodium ion transport; rhythmic process; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; circadian regulation of gene expression; transcription, DNA-templated; entrainment of circadian clock; negative regulation of JNK cascade; circadian regulation of translation; regulation of circadian rhythm; circadian rhythm; histone H3 acetylation; regulation of hair cycle; histone H4 acetylation; posttranscriptional regulation of gene expression; response to cAMP; regulation of p38MAPK cascade; negative regulation of transcription, DNA-templated; entrainment of circadian clock by photoperiod; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5187
	18626
	ENSG00000179094
	ENSMUSG00000020893
	O15534
	O35973
	NM_002616
	NM_001159367; NM_011065
	NP_002607
	NP_001152839; NP_035195
	Wikidata
View/Edit Human	View/Edit Mouse

Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179094 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020893 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, Lee CC (September 1997). "RIGUI, a putative mammalian ortholog of the Drosophila period gene". Cell. 90 (6): 1003–11. doi:10.1016/S0092-8674(00)80366-9. PMID 9323128.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020893 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9323128-5] Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, Lee CC (September 1997). "RIGUI, a putative mammalian ortholog of the Drosophila period gene". Cell. 90 (6): 1003–11. doi:10.1016/S0092-8674(00)80366-9. PMID 9323128.

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