Permanent neonatal diabetes

Permanent neonatal diabetes mellitus
Permanent neonatal diabetes mellitus
Other names	PNDM
Specialty	Neonatology

Permanent neonatal diabetes mellitus (PNDM) is a newly identified and potentially treatable form of monogenic diabetes. This type of neonatal diabetes is caused by activating mutations of the KCNJ11 gene, which codes for the Kir6.2 subunit of the beta cell K_ATP channel.^[1]^[2] This disease is considered to be a type of maturity onset diabetes of the young (MODY).

^ Hattersley A, Gloyn A, Pearson E, Edgehill E, Flanagan S, Ellard S. Novel monogenic diabetes results from activating mutations in Kir6.2 Presented at the First Meeting for the European Group for the Study of Monogenic Diabetes ("MODY in Malaga"); Malaga, Spain, 21 October 2004. Published form should be available in 2005.
^ Letha S, Mammen D, Valamparampil JJ (October 2007). "Permanent neonatal diabetes due to KCNJ11 gene mutation". Indian J Pediatr. 74 (10): 947–9. doi:10.1007/s12098-007-0175-y. PMID 17978456. Archived from the original on June 10, 2008.

[1] Hattersley A, Gloyn A, Pearson E, Edgehill E, Flanagan S, Ellard S. Novel monogenic diabetes results from activating mutations in Kir6.2 Presented at the First Meeting for the European Group for the Study of Monogenic Diabetes ("MODY in Malaga"); Malaga, Spain, 21 October 2004. Published form should be available in 2005.

[pmid17978456-2] Letha S, Mammen D, Valamparampil JJ (October 2007). "Permanent neonatal diabetes due to KCNJ11 gene mutation". Indian J Pediatr. 74 (10): 947–9. doi:10.1007/s12098-007-0175-y. PMID 17978456. Archived from the original on June 10, 2008.

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