Perospirone

Perospirone
Clinical data
Trade namesLullan
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding92%[1]
MetabolismHepatic[1]
Elimination half-life1.9–2.5 hours[1][2]
ExcretionRenal (0.4% as unchanged drug)[1]
Identifiers
  • (3aS,7aR)-2-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H30N4O2S
Molar mass426.58 g·mol−1
3D model (JSmol)
  • O=C4N(CCCCN1CCN(CC1)C\3=N\SCc2ccccc2/3)C(=O)[C@@H]5CCCC[C@H]45
  • InChI=1S/C24H32N4O2S/c29-23-20-9-3-4-10-21(20)24(30)28(23)12-6-5-11-26-13-15-27(16-14-26)22-19-8-2-1-7-18(19)17-31-25-22/h1-2,7-8,20-21H,3-6,9-17H2/t20-,21+ checkY
  • Key:GTAIPSDXDDTGBZ-OYRHEFFESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Perospirone (Lullan) is an atypical antipsychotic of the azapirone family.[1] It was introduced in Japan by Dainippon Sumitomo Pharma in 2001 for the treatment of schizophrenia and acute cases of bipolar mania.[3][4]

  1. ^ a b c d e Onrust SV, McClellan K (2001). "Perospirone". CNS Drugs. 15 (4): 329–37, discussion 338. doi:10.2165/00023210-200115040-00006. PMID 11463136. S2CID 262520276.
  2. ^ Yasui-Furukori N, Furukori H, Nakagami T, Saito M, Inoue Y, Kaneko S, Tateishi T (August 2004). "Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response". Therapeutic Drug Monitoring. 26 (4): 361–365. doi:10.1097/00007691-200408000-00004. PMID 15257064. S2CID 43362616.
  3. ^ de Paulis T (January 2002). "Perospirone (Sumitomo Pharmaceuticals)". Current Opinion in Investigational Drugs. 3 (1): 121–129. PMID 12054062.
  4. ^ "Now on the Market : New Antipsychotic "Lullan® Tablets" - serotonin-dopamine antagonist originated in Japan". Sumitomo Pharmaceuticals 2001 | News Release | Dainippon Sumitomo Pharma. 8 February 2001. Archived from the original on 24 February 2006.