Nuclear receptor protein found in humans
PPARA |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT |
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Identifiers |
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Aliases | PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha |
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External IDs | MGI: 104740; HomoloGene: 21047; GeneCards: PPARA; OMA:PPARA - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - renal medulla
- jejunal mucosa
- biceps brachii
- Skeletal muscle tissue of biceps brachii
- right lobe of liver
- retinal pigment epithelium
- muscle of thigh
- right ventricle
- body of tongue
- mucosa of sigmoid colon
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| Top expressed in | - left lobe of liver
- right kidney
- intercostal muscle
- brown adipose tissue
- digastric muscle
- human kidney
- sternocleidomastoid muscle
- thoracic diaphragm
- soleus muscle
- transitional epithelium of urinary bladder
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene.[5] Together with peroxisome proliferator-activated receptor delta and peroxisome proliferator-activated receptor gamma, PPAR-alpha is part of the subfamily of peroxisome proliferator-activated receptors. It was the first member of the PPAR family to be cloned in 1990 by Stephen Green and has been identified as the nuclear receptor for a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes.[6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186951 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022383 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sher T, Yi HF, McBride OW, Gonzalez FJ (June 1993). "cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor". Biochemistry. 32 (21): 5598–604. doi:10.1021/bi00072a015. PMID 7684926.
- ^ Issemann I, Green S (October 1990). "Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators". Nature. 347 (6294): 645–54. Bibcode:1990Natur.347..645I. doi:10.1038/347645a0. PMID 2129546. S2CID 4306126.