Peroxisome proliferator-activated receptor gamma

PPARG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5
External IDsOMIM: 601487; MGI: 97747; HomoloGene: 7899; GeneCards: PPARG; OMA:PPARG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127330
NM_011146
NM_001308352
NM_001308354

RefSeq (protein)

NP_001120802
NP_001295281
NP_001295283
NP_035276

Location (UCSC)Chr 3: 12.29 – 12.43 MbChr 6: 115.34 – 115.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene.[5][6][7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132170Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000440Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, et al. (1995). "Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping". Gene Expression. 4 (4–5): 281–99. PMC 6134382. PMID 7787419.
  6. ^ Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz MD, Moller DE, Berger J (July 1996). "Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2". Biochemical and Biophysical Research Communications. 224 (2): 431–7. doi:10.1006/bbrc.1996.1044. PMID 8702406.
  7. ^ Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, et al. (December 2006). "International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors". Pharmacological Reviews. 58 (4): 726–41. doi:10.1124/pr.58.4.5. PMID 17132851. S2CID 2240461.