Phage P22 tailspike protein

Bifunctional tail protein
PDB rendering based on 2XC1​.[1]
Identifiers
OrganismEnterobacteria phage P22
Symbol9
Entrez1262799
PDB2XC1
RefSeq (mRNA)NC_002371.2
RefSeq (Prot)NP_059644.1
Other data
EC number3.2.1.-
ChromosomeGenome: 0.02 - 0.02 Mb

The tailspike protein (P22TSP) of Enterobacteria phage P22 mediates the recognition and adhesion between the bacteriophage and the surface of Salmonella enterica cells. It is anchored within the viral coat and recognizes the O-antigen portion of the lipopolysaccharide (LPS) on the outer-membrane of Gram-negative bacteria. It possesses endoglycanase activity, serving to shorten the length of the O-antigen during infection.[2]

  1. ^ 2XC1​, 2VFM​, 2VKY​, 2VFP​, 2VFQ​, 2VFO​, 2VFN​, 2VNL​, 3TH0​, 1TYU​, 1TYV​, 1TYX​, 1TYW​, 1TSP​, 1CLW​, 1QRB​, 1QRC​, 1QQ1​, 1QA1​, 1QA2​, 1QA3​, 1LKT
  2. ^ Andres D, Baxa U, Hanke C, Seckler R, Barbirz S (Oct 2010). "Carbohydrate binding of Salmonella phage P22 tailspike protein and its role during host cell infection". Biochemical Society Transactions. 38 (5): 1386–1389. doi:10.1042/BST0381386. PMID 20863318.