Phenazolam

Phenazolam
Clinical data
Trade names	(none, designer drug)
Legal status
Legal status	CA: Schedule IV; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act; Illegal in Serbia and Italy;
Identifiers
	IUPAC name 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;
CAS Number	87213-50-1 ;
PubChem CID	1032830;
ChemSpider	887985;
UNII	2AVB9ZZ4ZS;
ChEMBL	ChEMBL1451229;
CompTox Dashboard (EPA)	DTXSID10236191;
Chemical and physical data
Formula	C17H12BrClN4
Molar mass	387.67 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4Cl;
	InChI InChI=1S/C17H12BrClN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3; Key:BUTCFAZTKZDYCN-UHFFFAOYSA-N;

Phenazolam, (Clobromazolam, DM-II-90, BRN 4550445) is a benzodiazepine derivative which acts as a potent sedative and hypnotic drug. It was first invented in the early 1980s,^[1] but was never developed for medical use. It has been sold over the internet as a designer drug, first being identified in seized samples by a laboratory in Sweden in March 2016.^[2]^[3]

^ Polívka Z, Holubek J, Metyš J, Šedivŷ Z, Protiva M (1983). "Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl) piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds". Collection of Czechoslovak Chemical Communications. 48 (12): 3433–43. doi:10.1135/cccc19833433.
^ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.
^ Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR (October 2020). "Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam". Journal of Analytical Toxicology. 45 (9): 1014–1027. doi:10.1093/jat/bkaa161. PMID 33048135.

[1] Polívka Z, Holubek J, Metyš J, Šedivŷ Z, Protiva M (1983). "Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl) piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds". Collection of Czechoslovak Chemical Communications. 48 (12): 3433–43. doi:10.1135/cccc19833433.

[2] "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.

[pmid33048135-3] Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR (October 2020). "Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam". Journal of Analytical Toxicology. 45 (9): 1014–1027. doi:10.1093/jat/bkaa161. PMID 33048135.

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