Pheniramine

Pheniramine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: A
Routes of
administration		Oral; injection (intramuscular or slow intravenous); topical (ophthalmic/nasal solution)
ATC code
Pharmacokinetic data
MetabolismHepatic hydroxylation, demethylation and glucuronidation
Elimination half-life16 - 19 hrs (oral), 8 - 7 hrs (i.v.)[1]
ExcretionRenal
Identifiers
  • N,N-Dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.506 Edit this at Wikidata
Chemical and physical data
FormulaC16H20N2
Molar mass240.350 g·mol−1
3D model (JSmol)
  • n1ccccc1C(c2ccccc2)CCN(C)C
  • InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3 checkY
  • Key:IJHNSHDBIRRJRN-UHFFFAOYSA-N checkY
  (verify)

Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.

It was patented in 1948.[2] Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.

  1. ^ Witte PU, Irmisch R, Hajdú P (January 1985). "Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration". International Journal of Clinical Pharmacology, Therapy, and Toxicology. 23 (1): 59–62. PMID 3988394.
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.