Phenylbutazone

Phenylbutazone
Skeletal formula
Ball-and-stick model
Clinical data
Trade namesButazolidine
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 4-Butyl-1,2-diphenyl-pyrazolidine-3,5-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.027 Edit this at Wikidata
Chemical and physical data
FormulaC19H20N2O2
Molar mass308.381 g·mol−1
3D model (JSmol)
  • O=C2N(c1ccccc1)N(C(=O)C2CCCC)c3ccccc3
  • InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3 checkY
  • Key:VYMDGNCVAMGZFE-UHFFFAOYSA-N checkY
  (verify)

Phenylbutazone, often referred to as "bute",[1] is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals.

In the United States and United Kingdom, it is no longer approved for human use (except in the United Kingdom for ankylosing spondylitis), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal. Positive phenylbutazone tests in horse meat were uncommon in the UK, however.[2]

  1. ^ Bogdanich W, Drape J (24 March 2012). "Death and Disarray at America's Racetracks". The New York Times.
  2. ^ "Horse meat investigation. Advice for consumers". Enforcement and regulation. Food Standards Agency. Retrieved 19 May 2013.