Philander Smith (January 11, 1765 – June 29, 1824) was a colonial-era settler of the Natchez District of Mississippi in North America. He was involved in the political movement to make the district an American territory rather than a Spanish colony. In 1807 he served as foreperson of the grand jury in the Aaron Burr treason indictment. He served in the Mississippi territorial legislature from 1804 to 1811.