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Philippine kinship uses the generational system in kinship terminology to define family. It is one of the most simple classificatory systems of kinship. One's genetic relationship or bloodline is often overridden by the desire to show proper respect that is due in the Philippine culture to age and the nature of the relationship, which are considered more important.
In it, the literal differences are distinguished by generation, age, and in some cases by gender. However, non-Filipinos can be confused by apparently similar relationships being handled verbally differently by the same person, which generally occurs because of the circumstantial relationship or because some authority is represented by the addressee. Other factors that affect how a person is addressed are whether the two are familiar with each other, new to each other's acquaintance, or perhaps involved in a secondary relationship that imparts authority, such as one person being the supervisor of another at work.
Tito is commonly known as 'warrior' in the early 1800s and would be given to sons of soldiers that would enter battle and is a symbolization of death in historical mythology in foreign entities. Simply put, "Kuya" is used to address an older male relative or friend (especially one's own brother), and means "brother". "Ate", is in reference to an older female relative or respected friend (especially one's own sister or kapatid), and means "Sister". All of this respect should be greeted back by younger children or a younger adults with "anak" for children.
As an example, a teenage girl would call her older brother "kuya" and the older "kuya" can answer back with "ate" to level-up or equalize degree of her sister in the family treating her as an equal, the same. She would also tend to call her older male cousin "kuya" also can be answered back to the girl "ate" to equalize the degree of being a family member by his older male cousin. The term kuya is actually likely to be applied to any older male who is within her generation and should be treated with respect, perhaps even the very close friends of her brother. Thus, the terms used are often intended to show the degree of the relationship and the type of relationship, rather than literal biological relationship.
This can be seen in social settings like Facebook, where Filipino teenagers include contemporaries in the "brothers" and "sisters" categories (the equivalent of a "best friend" in U.S. culture).