Phocaeicola vulgatus

Phocaeicola vulgatus
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Bacteroidota
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Phocaeicola
Species:
P. vulgatus
Binomial name
Phocaeicola vulgatus
García-López et al. 2020

Phocaeicola vulgatus, (formerly Bacteroides vulgatus),[1] is a mutualistic anaerobic Gram negative rod bacteria commonly found in the human gut microbiome and isolated from feces.[2] P. vulgatus has medical relevance and has been notable in scientific research due to its production of fatty acids, potential use as a probiotic, and associations with protecting against and worsening some inflammatory diseases.[3][4][5] Due to the difficulties in culturing anaerobic bacteria, P. vulgatus is still highly uncharacterised so efforts are being made to make use of multi-omic approaches to investigate the human gut microbiome more thoroughly in hopes to fully understand the role of this species in the development of and protection against diseases, as well as its potential uses in medicine and research.[6] Generally, P. vulgatus is considered as a beneficial bacteria that contributes to digestion and a balanced microbiome, but it has been known to cause opportunistic infections and induce or worsen inflammatory responses. Due to its abundance in the microbiome, some researchers are investigating these species in hopes that it will be a suitable model organism for gut microbiome research, like Bacteroides thetaiotaomicron.

  1. ^ García-López, Marina; Meier-Kolthoff, Jan P.; Tindall, Brian J.; Gronow, Sabine; Woyke, Tanja; Kyrpides, Nikos C.; Hahnke, Richard L.; Göker, Markus (2019-09-23). "Analysis of 1,000 Type-Strain Genomes Improves Taxonomic Classification of Bacteroidetes". Frontiers in Microbiology. 10: 2083. doi:10.3389/fmicb.2019.02083. ISSN 1664-302X. PMC 6767994. PMID 31608019.
  2. ^ Eggerth, Arnold H.; Gagnon, Bernard H. (April 1933). "The Bacteroides of Human Feces". Journal of Bacteriology. 25 (4): 389–413. doi:10.1128/jb.25.4.389-413.1933. ISSN 0021-9193. PMC 533498. PMID 16559622.
  3. ^ Miebach, Katharina; Finger, Maurice; Scherer, Alexandra Maria Katarina; Maaß, Constantin Alexander; Büchs, Jochen (2023-07-18). "Hydrogen online monitoring based on thermal conductivity for anaerobic microorganisms". Biotechnology and Bioengineering. 120 (8): 2199–2213. doi:10.1002/bit.28502. ISSN 0006-3592. PMID 37462090. S2CID 259948317.
  4. ^ Noor, Samah O; Ridgway, Karyn; Scovell, Louise; Kemsley, E Katherine; Lund, Elizabeth K; Jamieson, Crawford; Johnson, Ian T; Narbad, Arjan (December 2010). "Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota". BMC Gastroenterology. 10 (1): 134. doi:10.1186/1471-230X-10-134. ISSN 1471-230X. PMC 3002299. PMID 21073731.
  5. ^ Kang, Xing; Ng, Siu-Kin; Liu, Changan; Lin, Yufeng; Zhou, Yunfei; Kwong, Thomas N.Y.; Ni, Yunbi; Lam, Thomas Y.T.; Wu, William K.K.; Wei, Hong; Sung, Joseph J.Y.; Yu, Jun; Wong, Sunny H. (July 2023). "Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice". eBioMedicine. 93: 104670. doi:10.1016/j.ebiom.2023.104670. PMC 10314234. PMID 37343363.
  6. ^ Mills, Robert H.; Dulai, Parambir S.; Vázquez-Baeza, Yoshiki; Sauceda, Consuelo; Daniel, Noëmie; Gerner, Romana R.; Batachari, Lakshmi E.; Malfavon, Mario; Zhu, Qiyun; Weldon, Kelly; Humphrey, Greg; Carrillo-Terrazas, Marvic; Goldasich, Lindsay DeRight; Bryant, MacKenzie; Raffatellu, Manuela (2022-01-27). "Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity". Nature Microbiology. 7 (2): 262–276. doi:10.1038/s41564-021-01050-3. ISSN 2058-5276. PMC 8852248. PMID 35087228.