Phosalone

Phosalone
Names
Preferred IUPAC name
S-[(6-Chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl] O,O-diethyl phosphorodithioate
Other names
Zolone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.017.270 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3 checkY
    Key: IOUNQDKNJZEDEP-UHFFFAOYSA-N checkY
  • InChI=1/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3
    Key: IOUNQDKNJZEDEP-UHFFFAOYAA
  • Clc2ccc1c(OC(=O)N1CSP(=S)(OCC)OCC)c2
Properties
C12H15ClNO4PS2
Molar mass 367.80 g·mol−1
Appearance Colorless crystalline
Odor garlic
Density 1.39 g cm−3
Melting point 47.5 to 48 °C (117.5 to 118.4 °F; 320.6 to 321.1 K)
3.05 mg/L
Solubility many organic solvents
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide. It is developed by Rhône-Poulenc in France but EU eliminated it from pesticide registration in December 2006.

The median lethal dose of oral exposure in rat is 85 mg/kg and that of dermal is 390 mg/kg.[1]。It is a weak acetylcholinesterase inhibitor.[2] It is taken by not only oral and inhalation but skin and it causes toxic symptoms peculiar to organophosphorus compounds such as miosis, hypersalivation, hyperhidrosis, chest pressure, pulmonary edema and fecal incontinence.[3] It is flammable and decomposes to toxic gases such as phosphorus oxides, sulfur oxides and nitrogen oxides.[2] It is harmful especially to water creatures.

  1. ^ 製品安全データシート（安全衛生情報センター） Archived 2014-10-25 at the Wayback Machine
  2. ^ a b "国際化学物質安全性カード". Archived from the original on 2012-12-11. Retrieved 2012-09-06.
  3. ^ 植村振作・河村宏・辻万千子・冨田重行・前田静夫著 (2002). 農薬毒性の事典 改訂版. 三省堂. ISBN 978-4385356044.