Phosducin

PDC
Identifiers
AliasesPDC, MEKA, PHD, PhLOP, PhLP, phosducin
External IDsOMIM: 171490; MGI: 98090; HomoloGene: 1950; GeneCards: PDC; OMA:PDC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002597
NM_022576
NM_022577

NM_001159730
NM_024458

RefSeq (protein)

NP_002588
NP_072098
NP_002588.3

NP_001153202
NP_077778

Location (UCSC)Chr 1: 186.44 – 186.46 MbChr 1: 150.2 – 150.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosducin, also known as PDC, is a human protein and gene.[5] It belongs to the phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116703Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006007Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PDC phosducin".