| Phosphoenolpyruvate carboxykinase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 1khb. | |||||||||||
| Identifiers | |||||||||||
| Symbol | PEPCK | ||||||||||
| Pfam | PF00821 | ||||||||||
| InterPro | IPR008209 | ||||||||||
| PROSITE | PDOC00421 | ||||||||||
| SCOP2 | 1khf / SCOPe / SUPFAM | ||||||||||
| |||||||||||
| phosphoenolpyruvate carboxykinase 1 (soluble) | |
|---|---|
 Phosphoenolpyruvate carboxykinase (GTP, cytosolic) monomer, Human | |
| Identifiers | |
| Symbol | PCK1 |
| Alt. symbols | PEPCK-C |
| NCBI gene | 5105 |
| HGNC | 8724 |
| OMIM | 261680 |
| RefSeq | NM_002591 |
| Other data | |
| EC number | 4.1.1.32 |
| Locus | Chr. 20 q13.31 |
| phosphoenolpyruvate carboxykinase 2 (mitochondrial) | |
|---|---|
| Identifiers | |
| Symbol | PCK2 |
| Alt. symbols | PEPCK-M, PEPCK2 |
| NCBI gene | 5106 |
| HGNC | 8725 |
| OMIM | 261650 |
| RefSeq | NM_001018073 |
| Other data | |
| EC number | 4.1.1.32 |
| Locus | Chr. 14 q12 |
Phosphoenolpyruvate carboxykinase (EC 4.1.1.32, PEPCK) is an enzyme in the lyase family used in the metabolic pathway of gluconeogenesis. It converts oxaloacetate into phosphoenolpyruvate and carbon dioxide.[1][2][3]
It is found in two forms, cytosolic and mitochondrial.
- ^ Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, Perales JC (August 2014). "Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability". The Journal of Biological Chemistry. 289 (32): 22090–102. doi:10.1074/jbc.M114.566927. PMC 4139223. PMID 24973213.
- ^ Méndez-Lucas A, Duarte JA, Sunny NE, Satapati S, He T, Fu X, et al. (July 2013). "PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis". Journal of Hepatology. 59 (1): 105–13. doi:10.1016/j.jhep.2013.02.020. PMC 3910155. PMID 23466304.
- ^ Chakravarty K, Cassuto H, Reshef L, Hanson RW (2005). "Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C". Critical Reviews in Biochemistry and Molecular Biology. 40 (3): 129–54. doi:10.1080/10409230590935479. PMID 15917397. S2CID 633399.