Phosphoinositide-dependent kinase-1

PDPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H1W, 1OKY, 1OKZ, 1UU3, 1UU7, 1UU8, 1UU9, 1UVR, 1W1D, 1W1G, 1W1H, 1Z5M, 2BIY, 2PE0, 2PE1, 2PE2, 2R7B, 2VKI, 2XCH, 2XCK, 3H9O, 3HRC, 3HRF, 3ION, 3IOP, 3NAX, 3NAY, 3NUN, 3NUS, 3NUU, 3NUY, 3ORX, 3ORZ, 3OTU, 3PWY, 3QC4, 3QCQ, 3QCS, 3QCX, 3QCY, 3QD0, 3QD3, 3QD4, 3RCJ, 3RWP, 3RWQ, 3SC1, 4A06, 4A07, 4AW0, 4AW1, 4CT1, 4CT2, 4RQV, 4RRV, 4XX9, 5ACK, 5HO7, 5HO8, 5HKM, 5HNG
Identifiers
Aliases	PDPK1, PDK1, PDPK2, PRO0461, PDPK2P, Phosphoinositide-dependent kinase-1, 3-phosphoinositide dependent protein kinase 1
External IDs	OMIM: 605213; MGI: 1338068; HomoloGene: 37643; GeneCards: PDPK1; OMA:PDPK1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,537,979 bp[1] End 2,603,188 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,292,654 bp[2] End 24,369,898 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte middle temporal gyrus Brodmann area 23 bronchial epithelial cell parotid gland caput epididymis corpus epididymis mucosa of sigmoid colon external globus pallidus visceral pleura Top expressed in Rostral migratory stream nucleus accumbens seminiferous tubule ventromedial nucleus zygote pontine nuclei olfactory tubercle anterior amygdaloid area facial motor nucleus epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity phospholipase binding insulin receptor binding 3-phosphoinositide-dependent protein kinase activity protein serine/threonine kinase activity phospholipase activator activity protein binding ATP binding protein kinase binding kinase activity Cellular component cytoplasm cytosol cell projection membrane focal adhesion plasma membrane nucleoplasm cell junction nucleus perikaryon postsynaptic density cytoplasmic vesicle Biological process intracellular signal transduction regulation of transcription, DNA-templated extrinsic apoptotic signaling pathway negative regulation of protein kinase activity phosphorylation T cell costimulation stimulatory C-type lectin receptor signaling pathway positive regulation of release of sequestered calcium ion into cytosol negative regulation of transforming growth factor beta receptor signaling pathway hyperosmotic response transcription, DNA-templated platelet activation cellular response to epidermal growth factor stimulus Fc-epsilon receptor signaling pathway positive regulation of phospholipase activity protein phosphorylation negative regulation of cardiac muscle cell apoptotic process focal adhesion assembly negative regulation of toll-like receptor signaling pathway peptidyl-serine phosphorylation regulation of endothelial cell migration cellular response to insulin stimulus protein autophosphorylation regulation of mast cell degranulation peptidyl-threonine phosphorylation type B pancreatic cell development T cell receptor signaling pathway cell migration actin cytoskeleton organization regulation of I-kappaB kinase/NF-kappaB signaling calcium-mediated signaling negative regulation of neuron apoptotic process cellular response to brain-derived neurotrophic factor stimulus epidermal growth factor receptor signaling pathway positive regulation of protein localization to plasma membrane activation of protein kinase B activity positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of vascular endothelial cell proliferation positive regulation of sprouting angiogenesis negative regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5170 18607 Ensembl ENSG00000140992 ENSMUSG00000024122 UniProt O15530 Q9Z2A0 RefSeq (mRNA) NM_001261816 NM_002613 NM_031268 NM_001080773 NM_001286662 NM_011062 RefSeq (protein) NP_001248745 NP_002604 NP_112558 NP_001074242 NP_001273591 NP_035192 Location (UCSC) Chr 16: 2.54 – 2.6 Mb Chr 17: 24.29 – 24.37 Mb PubMed search [3] [4]
Wikidata
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In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans.^[5] It is implicated in the development and progression of melanomas.^[6]