Phosphoinositide 3-kinase

Phosphatidylinositol-4,5-bisphosphate 3-kinase
PIK-93 inhibitor (yellow) bound to the PI3K 110 gamma subunit .[1]
Identifiers
SymbolPI3K
PfamPF00454
InterProIPR000403
SMARTSM00146
PROSITEPDOC00710
SCOP23gmm / SCOPe / SUPFAM
OPM superfamily265
OPM protein3ml9
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Phosphoinositide 3-kinase
Identifiers
EC no.2.7.1.137
CAS no.115926-52-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).[2] The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.[3][4]

  1. ^ PDB: 2chz​; Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, et al. (May 2006). "A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling". Cell. 125 (4): 733–47. doi:10.1016/j.cell.2006.03.035. PMC 2946820. PMID 16647110.
  2. ^ "myo-inositol". Archived from the original on 2011-08-06. Retrieved 2006-01-28.
  3. ^ Giese N (2009). "Cell pathway on overdrive prevents cancer response to dietary restriction". PhysOrg.com. Retrieved 2009-04-22.
  4. ^ Kalaany NY, Sabatini DM (April 2009). "Tumours with PI3K activation are resistant to dietary restriction". Nature. 458 (7239): 725–31. Bibcode:2009Natur.458..725K. doi:10.1038/nature07782. PMC 2692085. PMID 19279572.