 Crystallographic structure of phospholipase A1. Red region denotes α helices, Green region denotes loops, and yellow region denotes β sheets. | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| EC no. | 3.1.1.32 | ||||||||
| CAS no. | 9043-29-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| phospholipase A1 member A | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PLA1A | ||||||
| NCBI gene | 51365 | ||||||
| HGNC | 17661 | ||||||
| OMIM | 607460 | ||||||
| RefSeq | NM_015900 | ||||||
| UniProt | Q53H76 | ||||||
| Other data | |||||||
| EC number | 3.1.1.32 | ||||||
| Locus | Chr. 3 q13.13-13.2 | ||||||
| |||||||
Phospholipase A1 (EC 3.1.1.32; systematic name: phosphatidylcholine 1-acylhydrolase) encoded by the PLA1A gene is a phospholipase enzyme which removes the 1-acyl group:[1]
- phosphatidylcholine + H2O ⇌ 2-acylglycerophosphocholine + a carboxylate
It is an enzyme that resides in a class of enzymes called phospholipase that hydrolyze phospholipids into fatty acids.[2] There are four classes, separated according to the type of reaction they catalyze. In particular, phospholipase A1 (PLA1) specifically catalyzes the cleavage at the sn-1 position of phospholipids, forming a fatty acid and a lysophospholipid.[3][4]
- ^ Phospholipase+A1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ DeSilva NS, Quinn PA (1999). "Characterization of phospholipase A1, A2, C activity in Ureaplasma urealyticum membranes". Mol. Cell. Biochem. 201 (1–2): 159–67. doi:10.1023/A:1007082507407. PMID 10630635. S2CID 22101516.
- ^ Richmond GS, Smith TK (2011). "Phospholipases A1". International Journal of Molecular Sciences. 12 (1): 588–612. doi:10.3390/ijms12010588. PMC 3039968. PMID 21340002.
- ^ Scandella CJ, Kornberg A (November 1971). "A membrane-bound phospholipase A1 purified from Escherichia coli". Biochemistry. 10 (24): 4447–56. doi:10.1021/bi00800a015. PMID 4946924.