| ribulose-phosphate 3-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 D-ribulose-5-phosphate 3-epimerase dodekamer, Francisella tularensis | |||||||||
| Identifiers | |||||||||
| EC no. | 5.1.3.1 | ||||||||
| CAS no. | 9024-20-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Ribulose-phosphate 3 epimerase family | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Ribul_P_3_epim | ||||||||||
| Pfam | PF00834 | ||||||||||
| InterPro | IPR000056 | ||||||||||
| PROSITE | PDOC00833 | ||||||||||
| SCOP2 | 1rpx / SCOPe / SUPFAM | ||||||||||
| |||||||||||
Phosphopentose epimerase (also known as ribulose-phosphate 3-epimerase and ribulose 5-phosphate 3-epimerase, EC 5.1.3.1) encoded in humans by the RPE gene[1] is a metalloprotein that catalyzes the interconversion between D-ribulose 5-phosphate and D-xylulose 5-phosphate.[2]
- D-ribulose 5-phosphate D-xylulose 5-phosphate
This reversible conversion is required for carbon fixation in plants – through the Calvin cycle – and for the nonoxidative phase of the pentose phosphate pathway.[3][4] This enzyme has also been implicated in additional pentose and glucuronate interconversions.
In Cupriavidus metallidurans two copies of the gene coding for PPE are known,[5] one is chromosomally encoded P40117, the other one is on a plasmid Q04539. PPE has been found in a wide range of bacteria, archaebacteria, fungi and plants. All the proteins have from 209 to 241 amino acid residues. The enzyme has a TIM barrel structure.
- ^ "RPE Gene - Ribulose-5-Phosphate-3-Epimerase". GeneCards. 3 April 2024. Retrieved 11 May 2024.
- ^ Cite error: The named reference
Akanawas invoked but never defined (see the help page). - ^ Liang W, Ouyang S, Shaw N, Joachimiak A, Zhang R, Liu ZJ (Feb 2011). "Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE". FASEB Journal. 25 (2): 497–504. doi:10.1096/fj.10-171207. PMC 6188353. PMID 20923965.
- ^ Mendz, George; Stuart Hazell (1991). "Evidence for a pentose phosphate pathway in Helicobacter pylori". FEMS Microbiology Letters. 84 (3): 331–336. doi:10.1111/j.1574-6968.1991.tb04619.x.
- ^ Kusian B, Yoo JG, Bednarski R, Bowien B (Nov 1992). "The Calvin cycle enzyme pentose-5-phosphate 3-epimerase is encoded within the cfx operons of the chemoautotroph Alcaligenes eutrophus". Journal of Bacteriology. 174 (22): 7337–44. doi:10.1128/jb.174.22.7337-7344.1992. PMC 207429. PMID 1429456.