PiXL (Photorefractive Intrastromal Cross-Linking) is a modern non-invasive non-surgical vision correction procedure.[1]
It is performed by applying riboflavin (vitamin B2) eye drops to the cornea and illuminating it with UVA light, which cross-links the collagen fibers within the cornea, making it stronger, changing the shape and improving the patient's vision.[2]
PiXL is a high-fluence corneal collagen cross-linking administered in a customizable pattern and intensity in order to flatten or steepen the cornea through corneal strengthening.[3] The specific application of UVA for each patient takes into account the refractive error and corneal topography.[4] The major components of the therapy are riboflavin injection and UVA irradiation, and the procedure is followed by a course of topical antibiotics and corticosteroids.[5]
PiXL is appropriate for patients with low myopia or hyperopia (mild nearsightedness or farsightedness) as a second line to conventional refractive surgeries (i.e. SMILE, LASIK, PRK, intraocular lens), and for patients who require correction of residual refractive error or refractive regression after conventional refractive surgeries.[1][4][6]