Pier Francesco Guala (15 September 1698 – 27 February 1757), also known as Pierfrancesco and Pietro Francesco, was an eighteenth-century Italian painter active for the most part in the region of his place of birth, Casale Monferrato.
Guala was the seventh of eight siblings of whom only he and a sister survived infancy. His mother died when he was five and he was brought up by his father, Lorenzo, who himself was a painter and perhaps related to the architect Sebastiano Guala.
Pier Francesco Guala died in Milan on 27 February 1757.