The International Civil Aviation Organization (ICAO) defines fatigue as "A physiological state of reduced mental or physical performance capability resulting from sleep loss or extended wakefulness, circadian phase, or workload."[1] The phenomenon places great risk on the crew and passengers of an airplane because it significantly increases the chance of pilot error.[2] Fatigue is particularly prevalent among pilots because of "unpredictable work hours, long duty periods, circadian disruption, and insufficient sleep".[2] These factors can occur together to produce a combination of sleep deprivation, circadian rhythm effects, and 'time-on task' fatigue.[2] Regulators attempt to mitigate fatigue by limiting the number of hours pilots are allowed to fly over varying periods of time.