 Bottle of piperacillin/tazobactam | |
| Combination of | |
|---|---|
| Piperacillin | Ureidopenicillin antibiotic |
| Tazobactam | Beta-lactamase inhibitor |
| Clinical data | |
| Trade names | Tazocin, Zosyn, others[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694003 |
| Routes of administration | Intravenous infusion |
| ATC code | |
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Piperacillin/tazobactam, sold under the brand name Tazocin among others, is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam.[4] The combination has activity against many Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.[4] It is used to treat pelvic inflammatory disease, intra-abdominal infection, pneumonia, cellulitis, and sepsis.[4] It is given by injection into a vein.[5]
Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea.[4] Serious adverse effects include Clostridioides difficile infection and allergic reactions including anaphylaxis.[4] Those who are allergic to other β-lactam are more likely to be allergic to piperacillin/tazobactam.[4] Use in pregnancy or breastfeeding appears to generally be safe.[6] It usually results in bacterial death through blocking their ability to make a cell wall.[4]
Piperacillin/tazobactam was approved for medical use in the United States in 1993.[4] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[5]
- ^ "Tazocin". Drugs.com. Retrieved 22 January 2020.
- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ "Product monograph brand safety updates". Health Canada. 6 June 2024. Retrieved 8 June 2024.
- ^ a b c d e f g h "Piperacillin Sodium and Tazobactam Sodium". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
- ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 373. ISBN 9780857111562.
- ^ "Piperacillin / tazobactam (Zosyn) Use During Pregnancy". Drugs.com. Retrieved 10 December 2017.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.