Piperazine

Piperazine
Names
Preferred IUPAC name
Piperazine[1]
Systematic IUPAC name
1,4-Diazacyclohexane
Other names
Hexahydropyrazine
Piperazidine
Diethylenediamine
1,4-Diazinane
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.003.463 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2 ☒N
    Key: GLUUGHFHXGJENI-UHFFFAOYSA-N ☒N
  • InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
  • C1CNCCN1
Properties
C4H10N2
Molar mass 86.138 g·mol−1
Appearance White crystalline solid
Melting point 106 °C (223 °F; 379 K)[2]
Boiling point 146 °C (295 °F; 419 K)[2] Sublimates
Freely soluble[2]
Acidity (pKa) 9.8
Basicity (pKb) 4.19[2]
-56.8·10−6 cm3/mol
Pharmacology
P02CB01 (WHO)
Pharmacokinetics:
60-70%
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 2: Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur. Flash point between 38 and 93 °C (100 and 200 °F). E.g. diesel fuelInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
2
2
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.[3] Piperazine exists as small alkaline deliquescent crystals with a saline taste.

The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group.[4]

  1. ^ "Front Matter". Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 142. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4.
  2. ^ a b c d Merck Index, 11th Edition, 7431
  3. ^ PubChem. "Piperazine". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-03-08.
  4. ^ "Piperazine - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2023-05-03.