Pitavastatin

Pitavastatin
Clinical data
Trade namesLivalo, Livazo, others
AHFS/Drugs.comMonograph
MedlinePlusa610018
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth (tablets)
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability60%
Protein binding96%
MetabolismLiver (CYP2C9, minimally)
Elimination half-life11 hours
ExcretionFaeces
Identifiers
  • (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.171.153 Edit this at Wikidata
Chemical and physical data
FormulaC25H24FNO4
Molar mass421.468 g·mol−1
3D model (JSmol)
  • O=C(O)C[C@H](O)C[C@H](O)/C=C/c1c(c3ccccc3nc1C2CC2)c4ccc(F)cc4
  • InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1 checkY
  • Key:VGYFMXBACGZSIL-MCBHFWOFSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pitavastatin (usually as a calcium salt) is a member of the blood cholesterol lowering medication class of statins.[1]

Like other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis.

It was patented in 1987 and approved for medical use in 2003.[2] It is available in Japan, South Korea and in India.[3] In the US, it received FDA approval in 2009.[4] Kowa Pharmaceuticals, a subsidiary of Kowa Company, is the owner of the American patent to pitavastatin.

  1. ^ Kajinami K, Takekoshi N, Saito Y (2003). "Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor". Cardiovascular Drug Reviews. 21 (3): 199–215. doi:10.1111/j.1527-3466.2003.tb00116.x. PMID 12931254.
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495.
  3. ^ "Zydus Cadila launches pitavastatin in India". Archived from the original on 26 September 2017. Retrieved 28 May 2006.
  4. ^ "Pitavastatin (Livalo)--the seventh statin". The Medical Letter on Drugs and Therapeutics. 52 (1343): 57–8. July 2010. PMID 20651638.