Plakoglobin

JUP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IFQ
Identifiers
Aliases	JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG
External IDs	OMIM: 173325; MGI: 96650; HomoloGene: 1680; GeneCards: JUP; OMA:JUP - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,754,604 bp[1] End 41,786,931 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.47 cM Start 100,259,784 bp[2] End 100,288,589 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of pharynx nipple gingival epithelium skin of arm human penis vulva skin of thigh apex of heart Top expressed in lip esophagus corneal stroma skin of back muscle of thigh skin of external ear stomach pyloric antrum epithelium of stomach yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity transcription coactivator activity structural constituent of cell wall structural molecule activity signal transducer activity protein binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication protein phosphatase binding protein kinase binding alpha-catenin binding cell adhesion molecule binding cadherin binding Cellular component cytoplasm cytosol gamma-catenin-TCF7L2 complex lateral plasma membrane membrane intercalated disc cell-cell junction focal adhesion adherens junction plasma membrane desmosome hemidesmosome cell junction apicolateral plasma membrane protein-DNA complex Z discdkac actin cytoskeleton zonula adherens cytoplasmic side of plasma membrane catenin complex fascia adherens cytoskeleton intermediate filament extracellular exosome nucleus extracellular matrix cornified envelope extracellular region specific granule lumen ficolin-1-rich granule lumen Biological process adherens junction assembly protein heterooligomerization positive regulation of canonical Wnt signaling pathway positive regulation of DNA-binding transcription factor activity bundle of His cell-Purkinje myocyte adhesion involved in cell communication endothelial cell-cell adhesion cellular response to indole-3-methanol desmosome assembly cell adhesion regulation of cell population proliferation detection of mechanical stimulus positive regulation of protein import into nucleus adherens junction organization regulation of heart rate by cardiac conduction cell migration regulation of ventricular cardiac muscle cell action potential skin development signal transduction keratinization neutrophil degranulation cornification protein localization to plasma membrane cell-cell adhesion positive regulation of cell-matrix adhesion negative regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3728 16480 Ensembl ENSG00000173801 ENSMUSG00000001552 UniProt P14923 Q02257 RefSeq (mRNA) NM_002230 NM_021991 NM_001352773 NM_001352774 NM_001352775 NM_001352776 NM_001352777 NM_010593 RefSeq (protein) NP_002221 NP_068831 NP_001339702 NP_001339703 NP_001339704 NP_001339705 NP_001339706 NP_034723 Location (UCSC) Chr 17: 41.75 – 41.79 Mb Chr 11: 100.26 – 100.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene.^[5] Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia.