Plasma kallikrein

KLKB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OGY, 2ANW, 4OGX, 4ZJ4, 2ANY, 4ZJ5, 4ZJ6
Identifiers
Aliases	KLKB1, KLK3, PPK, PKKD, PKK, kallikrein B1
External IDs	OMIM: 229000; MGI: 102849; HomoloGene: 68097; GeneCards: KLKB1; OMA:KLKB1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	186,258,471 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	45,747,896 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gonad; ; tendon of biceps brachii; ; body of pancreas; ; testicle; ; pancreatic epithelial cell; ; jejunal mucosa; ; dorsal motor nucleus of vagus nerve; ; middle temporal gyrus; ; Epithelium of choroid plexus;
	Top expressed in
	left lobe of liver; ; right lobe of liver; ; spermatid; ; sexually immature organism; ; neural layer of retina; ; epithelium of lens; ; right kidney; ; respiratory epithelium; ; nose; ; nasal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine-type peptidase activity; serine-type endopeptidase activity; peptidase activity; protein binding; hydrolase activity;
Cellular component	extracellular exosome; plasma membrane; extracellular region; extracellular space;
Biological process	positive regulation of fibrinolysis; zymogen activation; Factor XII activation; proteolysis; fibrinolysis; plasminogen activation; extracellular matrix disassembly; inflammatory response; hemostasis; blood coagulation; blood coagulation, intrinsic pathway;
	Sources:Amigo / QuickGO
Orthologs
	3818
	16621
	ENSG00000164344
	ENSMUSG00000109764
	P03952
	P26262
	NM_000892; NM_001318394; NM_001318396
	NM_008455
	NP_000883; NP_001305323; NP_001305325
	NP_032481
	Wikidata
View/Edit Human	View/Edit Mouse

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PubMed	articles
NCBI	proteins

Plasma kallikrein
Plasma kallikrein
Identifiers
EC no.	3.4.21.34
CAS no.	410538-33-9
Alt. names	serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Plasma kallikrein (EC 3.4.21.34) is an enzyme^[5]^[6]^[7]^[8]^[9] that catalyses the following chemical reaction:

Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin

Plasma kallikrein and its precursor are encoded by the KLKB1 gene.^[10]^[11]

This enzyme is formed from prekallikrein (Fletcher factor) by factor XIIa.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109764 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heimark RL, Davie EW (1981). "[14] Bovine and human plasma prekallikrein". Bovine and human plasma prekallikrein. Methods in Enzymology. Vol. 80 Pt C. pp. 157–72. doi:10.1016/s0076-6879(81)80016-x. ISBN 978-0-12-181980-4. PMID 6918767.
^ McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20 (25): 7196–206. doi:10.1021/bi00528a022. PMID 6976185.
^ Silverberg M, Kaplan AP (1988). "[8] Prekallikrein". Prekallikrein. Methods in Enzymology. Vol. 163. pp. 85–95. doi:10.1016/0076-6879(88)63010-2. ISBN 978-0-12-182064-0. PMID 3237096.
^ Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein". DNA. 8 (8): 563–74. doi:10.1089/dna.1989.8.563. PMID 2598771.
^ Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chemical & Pharmaceutical Bulletin. 37 (11): 3108–11. doi:10.1248/cpb.37.3108. PMID 2534361.
^ Yu H, Bowden DW, Spray BJ, Rich SS, Freedman BI (April 1998). "Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease". Hypertension. 31 (4): 906–11. doi:10.1161/01.hyp.31.4.906. PMID 9535413.
^ Chung DW, Fujikawa K, McMullen BA, Davie EW (August 1986). "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats". Biochemistry. 25 (9): 2410–7. doi:10.1021/bi00357a017. PMID 3521732.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164344 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000109764 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Heimark RL, Davie EW (1981). "[14] Bovine and human plasma prekallikrein". Bovine and human plasma prekallikrein. Methods in Enzymology. Vol. 80 Pt C. pp. 157–72. doi:10.1016/s0076-6879(81)80016-x. ISBN 978-0-12-181980-4. PMID 6918767.

[6] McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20 (25): 7196–206. doi:10.1021/bi00528a022. PMID 6976185.

[7] Silverberg M, Kaplan AP (1988). "[8] Prekallikrein". Prekallikrein. Methods in Enzymology. Vol. 163. pp. 85–95. doi:10.1016/0076-6879(88)63010-2. ISBN 978-0-12-182064-0. PMID 3237096.

[8] Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein". DNA. 8 (8): 563–74. doi:10.1089/dna.1989.8.563. PMID 2598771.

[9] Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chemical & Pharmaceutical Bulletin. 37 (11): 3108–11. doi:10.1248/cpb.37.3108. PMID 2534361.

[pmid9535413-10] Yu H, Bowden DW, Spray BJ, Rich SS, Freedman BI (April 1998). "Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease". Hypertension. 31 (4): 906–11. doi:10.1161/01.hyp.31.4.906. PMID 9535413.

[pmid3521732-11] Chung DW, Fujikawa K, McMullen BA, Davie EW (August 1986). "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats". Biochemistry. 25 (9): 2410–7. doi:10.1021/bi00357a017. PMID 3521732.

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