Platelet-derived growth factor receptor

Platelet-derived growth factor receptor
Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF-B (cyan and green).[1]
Identifiers
SymbolPDGFR
PfamPF04692
InterProIPR006782
Membranome1204
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
platelet-derived growth factor receptor, alpha polypeptide
Identifiers
SymbolPDGFRA
NCBI gene5156
HGNC8803
OMIM173490
RefSeqNM_006206
UniProtP16234
Other data
LocusChr. 4 q12
Search for
StructuresSwiss-model
DomainsInterPro
platelet-derived growth factor receptor, beta polypeptide
Identifiers
SymbolPDGFRB
Alt. symbolsPDGFR
NCBI gene5159
HGNC8804
OMIM173410
RefSeqNM_002609
UniProtP09619
Other data
LocusChr. 5 q31-q32
Search for
StructuresSwiss-model
DomainsInterPro

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer.[2] There are two forms of the PDGF-R, alpha and beta each encoded by a different gene.[3] Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.[4]

  1. ^ PDB: 3MJG​; Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X (June 2010). "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". Proceedings of the National Academy of Sciences of the United States of America. 107 (25): 11307–12. Bibcode:2010PNAS..10711307H. doi:10.1073/pnas.1000806107. PMC 2895058. PMID 20534510.; rendered using PyMOL.
  2. ^ Williams LT (March 1989). "Signal transduction by the platelet-derived growth factor receptor". Science. 243 (4898): 1564–70. Bibcode:1989Sci...243.1564W. doi:10.1126/science.2538922. PMID 2538922.
  3. ^ Heldin CH, Westermark B (April 1989). "Platelet-derived growth factor: three isoforms and two receptor types". Trends in Genetics. 5 (4): 108–11. doi:10.1016/0168-9525(89)90040-1. PMID 2543106.
  4. ^ Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B (March 1992). "Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes". Kidney International. 41 (3): 571–4. doi:10.1038/ki.1992.84. PMID 1315403.