Platelet-derived growth factor receptor A

PDGFRA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDGFRA, CD140A, PDGFR-2, PDGFR2, RHEGAS9, platelet derived growth factor receptor alpha
External IDsOMIM: 173490; MGI: 97530; HomoloGene: 31361; GeneCards: PDGFRA; OMA:PDGFRA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006206
NM_001347827
NM_001347828
NM_001347829
NM_001347830

NM_001083316
NM_011058
NM_001347718
NM_001347719

RefSeq (protein)

NP_001334756
NP_001334757
NP_001334758
NP_001334759
NP_006197

NP_001076785
NP_001334647
NP_001334648
NP_035188

Location (UCSC)Chr 4: 54.23 – 54.3 MbChr 5: 75.31 – 75.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded in the human by the PDGFRA gene. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the embryonic development of certain tissues and organs, and for their maintenance, particularly hematologic tissues, throughout life. Mutations in PDGFRA, are associated with an array of clinically significant neoplasms, notably ones of the clonal hypereosinophilia class of malignancies, as well as gastrointestinal stromal tumors (GISTs).

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134853Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029231Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.