| Pleckstrin-1 | |||||||
|---|---|---|---|---|---|---|---|
 Ribbon diagram of the C-terminal pleckstrin homology domain of pleckstrin-1 bound to inositol 1,2,3,4,5-pentaphosphate (PDB ID 2I5C) | |||||||
| Identifiers | |||||||
| Symbol | PLEK | ||||||
| NCBI gene | 5341 | ||||||
| HGNC | 9070 | ||||||
| OMIM | 173570 | ||||||
| RefSeq | NM_002664 | ||||||
| UniProt | P08567 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p13.3 | ||||||
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| Pleckstrin-2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PLEK2 | ||||||
| NCBI gene | 26499 | ||||||
| HGNC | 19238 | ||||||
| OMIM | 608007 | ||||||
| PDB | 1X1G | ||||||
| RefSeq | NM_016445 | ||||||
| UniProt | Q9NYT0 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q23.3q24.1 | ||||||
| Wikidata | Q18038260 | ||||||
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Pleckstrins are a family of proteins found in platelets[1] and other cells. The name derives from platelet and leukocyte C kinase substrate and the KSTR string of amino acids. The prototype protein, now called pleckstrin-1, was first identified in 1979 as the major substrate of protein kinase C in platelets.[2] The homolog pleckstrin-2 is more widely expressed in tissues.[3]
The pleckstrin homology domain (PH domain) was named after pleckstrin-1.[2]
- ^ Harlan JE, Hajduk PJ, Yoon HS, Fesik SW (September 1994). "Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate". Nature. 371 (6493): 168–170. Bibcode:1994Natur.371..168H. doi:10.1038/371168a0. hdl:10356/94313. PMID 8072546. S2CID 4321763.
- ^ a b Edlich C, Stier G, Simon B, Sattler M, Muhle-Goll C (February 2005). "Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin". Structure. 13 (2): 277–286. doi:10.1016/j.str.2004.11.012. PMID 15698571.
- ^ Wang G, Zhou Q, Xu Y, Zhao B (2021). "Emerging Roles of Pleckstrin-2 Beyond Cell Spreading". Frontiers in Cell and Developmental Biology. 9: 768238. doi:10.3389/fcell.2021.768238. PMC 8637889. PMID 34869363.