Pleconaril

Pleconaril
Clinical data
Routes of
administration		Oral, intranasal
ATC code
Legal status
Legal status
  • ?
Pharmacokinetic data
Bioavailability70% (oral)
Protein binding>99%
MetabolismHepatic
Excretion<1% excreted unchanged in urine
Identifiers
  • 3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]
    phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.208.947 Edit this at Wikidata
Chemical and physical data
FormulaC18H18F3N3O3
Molar mass381.355 g·mol−1
3D model (JSmol)
  • FC(F)(F)c1nc(no1)c3cc(c(OCCCc2onc(c2)C)c(c3)C)C
  • InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3 checkY
  • Key:KQOXLKOJHVFTRN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pleconaril (Picovir[1]) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections.[2] Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus[3] and Rhinovirus.[4] It has shown useful activity against the dangerous enterovirus D68.[5]

  1. ^ "Pleconaril may shorten common cold". Pharma News - Latest Pharma & Pharmaceutical news & updates. 2000. Archived from the original on 6 October 2014.
  2. ^ Clinical trial number NCT00394914 for "Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295AM2)" at ClinicalTrials.gov
  3. ^ Pevear DC, Tull TM, Seipel ME, Groarke JM (September 1999). "Activity of pleconaril against enteroviruses". Antimicrobial Agents and Chemotherapy. 43 (9): 2109–2115. doi:10.1128/AAC.43.9.2109. PMC 89431. PMID 10471549.
  4. ^ Turner RB, Hendley JO (November 2005). "Virucidal hand treatments for prevention of rhinovirus infection". The Journal of Antimicrobial Chemotherapy. 56 (5): 805–807. doi:10.1093/jac/dki329. PMID 16159927.
  5. ^ Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, et al. (January 2015). "Structure and inhibition of EV-D68, a virus that causes respiratory illness in children". Science. 347 (6217): 71–74. Bibcode:2015Sci...347...71L. doi:10.1126/science.1261962. PMC 4307789. PMID 25554786.