| Plexin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Plexin extracellular domain | |||||||||
| Identifiers | |||||||||
| Symbol | PLXN | ||||||||
| Pfam | PF08337 | ||||||||
| InterPro | IPR031148 | ||||||||
| Membranome | 17 | ||||||||
| |||||||||
A plexin is a protein which acts as a receptor for semaphorin family signaling proteins.[1][2][3] It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin.[1][4] Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.[5][6]
- ^ a b Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, White LE (2012). Neuroscience (5th ed.). Sunderland, Mass.: Sinauer Associates. pp. 517–518. ISBN 978-0-87893-646-5. OCLC 754389847.
- ^ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS (December 1998). "Plexin A is a neuronal semaphorin receptor that controls axon guidance". Cell. 95 (7): 903–16. doi:10.1016/S0092-8674(00)81715-8. PMID 9875845.
- ^ Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY (August 2016). "Structural Basis for Plexin Activation and Regulation". Neuron. 91 (3): 548–60. doi:10.1016/j.neuron.2016.06.018. PMC 4980550. PMID 27397516.
- ^ Janssen BJ, Malinauskas T, Weir GA, Cader MZ, Siebold C, Jones EY (December 2012). "Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex". Nature Structural & Molecular Biology. 19 (12): 1293–9. doi:10.1038/nsmb.2416. PMC 3590443. PMID 23104057.
- ^ Ellenbroek SI, Collard JG (November 2007). "Rho GTPases: functions and association with cancer". Clinical & Experimental Metastasis. 24 (8): 657–72. doi:10.1007/s10585-007-9119-1. PMID 18000759. S2CID 680659.
- ^ Ayoob JC, Yu HH, Terman JR, Kolodkin AL (July 2004). "The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion". The Journal of Neuroscience. 24 (30): 6639–49. doi:10.1523/JNEUROSCI.1104-04.2004. PMC 6729715. PMID 15282266.