Poison River is a graphic novel by American cartoonist Gilbert Hernandez, published in 1994 after serialization from 1989 to 1993 in the comic book Love and Rockets. The story follows the life of the character Luba from her birth until her arrival in Palomar, the fictional Central American village in which most of Hernandez's stories in Love and Rockets take place.
The non-linear, magic realist story is complex and experimental. It traces the first eighteen years of Luba and her growing extended family during the 1950s–70s as they trek through a fictional Latin American country, while social and political events intrude upon their lives. Each chapter focuses on a different character—Luba herself rarely takes center stage. The story ends with Luba and her family appearing at the outskirts of the village of Palomar at the point when Hernandez's first Palomar story begins.
Long-time readers of Love and Rockets found the serialization of Poison River difficult to follow, and new readers found it disorienting and offputting. Unlike in his previous serial, Human Diastrophism, Hernandez made no attempt to mold the installments into episodes to fit the serial nature of Love and Rockets. When Poison River appeared in book form in 1994, Hernandez expanded the page count and altered and added panels to improve the reading experience. The book was a turning point for Hernandez and his approach to comics and is an early example of the growing pains the graphic novel form suffered in the 1980s and 1990s.