Polycomb protein EED

EED
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IIW, 3IIY, 3IJ0, 3IJ1, 3IJC, 3JPX, 3JZG, 3JZH, 3JZN, 3K26, 3K27, 4X3E, 5IJ7, 5IJ8, 5HYN
Identifiers
Aliases	EED, HWAIT1, embryonic ectoderm development, COGIS
External IDs	OMIM: 605984; MGI: 95286; HomoloGene: 2814; GeneCards: EED; OMA:EED - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	86,278,813 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	89,630,191 bp
RNA expression pattern
	Top expressed in
	lymph node; ; cerebellar vermis; ; cerebellar hemisphere; ; canal of the cervix; ; right uterine tube; ; epithelium of bronchus; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; left ovary; ; ventricular zone;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; yolk sac; ; primitive streak; ; morula; ; morula; ; medullary collecting duct; ; Gonadal ridge; ; ureter;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding; identical protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; histone methyltransferase activity; histone methyltransferase activity (H3-K27 specific); nucleosome binding;
Cellular component	sex chromatin; ESC/E(Z) complex; chromosome; pronucleus; nucleus; nucleoplasm; cytosol;
Biological process	regulation of gene expression by genetic imprinting; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of gene expression, epigenetic; spinal cord development; positive regulation of histone H3-K27 methylation; histone methylation; negative regulation of transcription, DNA-templated; regulation of adaxial/abaxial pattern formation; histone H3-K27 methylation; cellular response to leukemia inhibitory factor; negative regulation of G0 to G1 transition; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	8726
	13626
	ENSG00000074266
	ENSMUSG00000030619
	O75530
	Q921E6
	NM_001308007; NM_003797; NM_152991; NM_001330334
	NM_021876
	NP_001294936; NP_001317263; NP_003788
	NP_068676
	Wikidata
View/Edit Human	View/Edit Mouse

Polycomb protein EED is a protein that in humans is encoded by the EED gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074266 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030619 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Nov 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.
^ Schumacher A, Lichtarge O, Schwartz S, Magnuson T (Jan 1999). "The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation". Genomics. 54 (1): 79–88. doi:10.1006/geno.1998.5509. PMID 9806832.
^ "Entrez Gene: EED embryonic ectoderm development".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074266 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030619 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765275-5] Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Nov 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.

[pmid9806832-6] Schumacher A, Lichtarge O, Schwartz S, Magnuson T (Jan 1999). "The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation". Genomics. 54 (1): 79–88. doi:10.1006/geno.1998.5509. PMID 9806832.

[entrez-7] "Entrez Gene: EED embryonic ectoderm development".

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