Polymyxin

Colistin
Polymyxin B (R=H is polymyxin B2, R=CH3 is polymyxin B1)

Polymyxins are antibiotics. Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. They work mostly by breaking up the bacterial cell membrane. They are part of a broader class of molecules called nonribosomal peptides.

They are produced in nature by Gram-positive bacteria such as Paenibacillus polymyxa.