Pomalidomide

Pomalidomide
Clinical data
Trade namesPomalyst, Imnovid
AHFS/Drugs.comMonograph
MedlinePlusa613030
License data
Pregnancy
category
  • AU: X (High risk)[1]
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability73% (at least)[9]
Protein binding12–44%
MetabolismLiver (mostly CYP1A2- and CYP3A4-mediated; some minor contributions by CYP2C19 and CYP2D6)
Elimination half-life7.5 hours
ExcretionUrine (73%), faeces (15%)
Identifiers
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.232.884 Edit this at Wikidata
Chemical and physical data
FormulaC13H11N3O4
Molar mass273.248 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
  • InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) ☒N
  • Key:UVSMNLNDYGZFPF-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Pomalidomide, sold under the brand names Pomalyst and Imnovid,[7][8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma.[7]

Pomalidomide was approved for medical use in the United States in February 2013,[10] and in the European Union in August 2013.[8] It is available as a generic medication.[11]

  1. ^ "Pomalidomide (Pomalyst) Use During Pregnancy". Drugs.com. 14 May 2020. Archived from the original on 25 January 2021. Retrieved 21 September 2020.
  2. ^ "Pomalidomide Medicianz/ Pomalimed/ Pomalidomide Medsurge (Medicianz Healthcare Pty Ltd)". Therapeutic Goods Administration (TGA). 5 December 2022. Archived from the original on 18 March 2023. Retrieved 9 April 2023.
  3. ^ "Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 10 April 2023. Retrieved 10 April 2023.
  4. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
  5. ^ "Pomalyst Product information". Health Canada. Retrieved 16 December 2023.
  6. ^ "Imnovid 1 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 16 June 2020. Archived from the original on 26 October 2020. Retrieved 21 September 2020.
  7. ^ a b c "Pomalyst- pomalidomide capsule". DailyMed. 7 December 2017. Archived from the original on 20 October 2020. Retrieved 21 September 2020.
  8. ^ a b c Cite error: The named reference Imnovid EPAR was invoked but never defined (see the help page).
  9. ^ "Imnovid 1 mg Hard Capsules. Summary of Product Characteristics. 5.2 Pharmacokinetic properties" (PDF). Celgene Europe Ltd. p. 22. Archived (PDF) from the original on 27 June 2016. Retrieved 21 August 2016.
  10. ^ "Drug Approval Package: Pomalyst (pomalidomide) Capsules NDA #204026". U.S. Food and Drug Administration (FDA). 8 February 2013. Archived from the original on 29 March 2021. Retrieved 21 September 2020.
  11. ^ "2020 First Generic Drug Approvals". U.S. Food and Drug Administration. 23 February 2021. Archived from the original on 26 September 2021. Retrieved 12 May 2023.