Posidonius or Poseidonios may refer to:
- Poseidonios the Macedonian (3rd century BC?), a siege engineer mentioned by Biton of Pergamon
- Posidonius (1st century BC), Stoic polymath
- Posidonius (bishop of Urgell), bishop between AD 814 and 823
- Posidonius (crater), a lunar impact crater
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