Post-transcriptional regulation

Not to be confused with Post-translational regulation.

Post-transcriptional regulation is the control of gene expression at the RNA level. It occurs once the RNA polymerase has been attached to the gene's promoter and is synthesizing the nucleotide sequence. Therefore, as the name indicates, it occurs between the transcription phase and the translation phase of gene expression. These controls are critical for the regulation of many genes across human tissues.[1][2] It also plays a big role in cell physiology, being implicated in pathologies such as cancer and neurodegenerative diseases.[3]

  1. ^ Alberts B (18 November 2014). Molecular biology of the cell (Sixth ed.). New York, NY. ISBN 978-0-8153-4432-2. OCLC 887605755.{{cite book}}: CS1 maint: location missing publisher (link)
  2. ^ Franks A, Airoldi E, Slavov N (May 2017). "Post-transcriptional regulation across human tissues". PLOS Computational Biology. 13 (5): e1005535. Bibcode:2017PLSCB..13E5535F. doi:10.1371/journal.pcbi.1005535. PMC 5440056. PMID 28481885.
  3. ^ Dassi E (2017). "Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins". Frontiers in Molecular Biosciences. 4: 67. doi:10.3389/fmolb.2017.00067. PMC 5626838. PMID 29034245.